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Shear Stress Drives the Cleavage Activation of Protease-Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer Cells.
Zhou M, Li K, Luo KQ. Zhou M, et al. Adv Sci (Weinh). 2023 Sep;10(25):e2301059. doi: 10.1002/advs.202301059. Epub 2023 Jul 3. Adv Sci (Weinh). 2023. PMID: 37395651 Free PMC article.
Mesotrypsin (PRSS3), protease-activated receptor 2 (PAR2), and the subunit of activating protein 1, Fos-related antigen 1 (FOSL1), are upregulated by SS, and their high expression is responsible for promoting invasion and metastasis. SS triggers PRSS3 to cleave the N-termi …
Mesotrypsin (PRSS3), protease-activated receptor 2 (PAR2), and the subunit of activating protein 1, Fos-related antigen 1 (FOSL1), are upreg …
Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.
Sun L, Li PB, Yao YF, Xiu AY, Peng Z, Bai YH, Gao YJ. Sun L, et al. World J Gastroenterol. 2018 Mar 14;24(10):1120-1133. doi: 10.3748/wjg.v24.i10.1120. World J Gastroenterol. 2018. PMID: 29563756 Free PMC article.
Cell proliferation and metastasis were assessed both in vitro and in vitro. Immunoblotting was carried out to monitor the levels of mitogen-activated protein kinase (MAPK) and epithelial-mesenchymal transition markers. ...Patients with high PAR2 levels had advanced tumor s …
Cell proliferation and metastasis were assessed both in vitro and in vitro. Immunoblotting was carried out to monitor the levels of m …
Integrative multiomics analysis identifies a metastasis-related gene signature and the potential oncogenic role of EZR in breast cancer.
Xiao G, Cheng F, Yuan J, Lu W, Wang P, Fan H. Xiao G, et al. Oncol Res. 2022 Dec 6;30(1):35-51. doi: 10.32604/or.2022.026616. eCollection 2022. Oncol Res. 2022. PMID: 37304008 Free PMC article.
Distant metastasis is a major cause of increased mortality in breast cancer patients, but the mechanisms underlying breast cancer metastasis remain poorly understood. In this study, we aimed to identify a metastasis-related gene (MRG) signature for predicting …
Distant metastasis is a major cause of increased mortality in breast cancer patients, but the mechanisms underlying breast cancer …
Downregulation of matriptase suppresses the PAR‑2/PLCγ2/PKC‑mediated invasion and migration abilities of MCF‑7 breast cancer cells.
Kim JM, Park J, Noh EM, Song HK, Kang SY, Jung SH, Kim JS, Youn HJ, Lee YR. Kim JM, et al. Oncol Rep. 2021 Dec;46(6):247. doi: 10.3892/or.2021.8198. Epub 2021 Oct 5. Oncol Rep. 2021. PMID: 34608498 Free PMC article.
Matriptases, members of the type II transmembrane serine protease family, are cell surface proteolytic enzymes that mediate tumor invasion and metastasis. Matriptase is highly expressed in breast cancer and is associated with poor patient outcome. ...These findings shed li …
Matriptases, members of the type II transmembrane serine protease family, are cell surface proteolytic enzymes that mediate tumor invasion a …
Predictive value of protease-activated receptor-2 (PAR(2) ) in cervical cancer metastasis.
He S, Xu M, Xiong Z, Hu Y, Huo Q, Lu J, Lin Y, Yang L. He S, et al. J Cell Mol Med. 2021 Feb;25(3):1415-1424. doi: 10.1111/jcmm.16227. Epub 2020 Dec 23. J Cell Mol Med. 2021. PMID: 33369107 Free PMC article.
Metastasis is the primary cause of an unfavourable prognosis in patients with malignant cancer. ...Most importantly, the Cancer Genome Atlas (TCGA) data set analysis showed that the area under the curve (AUC) of the PAR(2) model was significantly greater than that of the t …
Metastasis is the primary cause of an unfavourable prognosis in patients with malignant cancer. ...Most importantly, the Cancer Genom …
Protease-activated receptor 2 promotes actomyosin dependent transforming microvesicles generation from human breast cancer.
Das K, Prasad R, Singh A, Bhattacharya A, Roy A, Mallik S, Mukherjee A, Sen P. Das K, et al. Mol Carcinog. 2018 Dec;57(12):1707-1722. doi: 10.1002/mc.22891. Epub 2018 Sep 5. Mol Carcinog. 2018. PMID: 30129687
Microvesicles (MVs), a plasma membrane shredded component, has recently been identified as an important contributor to human breast cancer metastasis. However, the role of PAR2 in promoting MVs generation from breast cancer cells remains largely unexplored. ...Understandin …
Microvesicles (MVs), a plasma membrane shredded component, has recently been identified as an important contributor to human breast cancer …
PAR2 knock-out C57Bl6 mice as a model for evaluating metastases of cancer cells: pilot in vivo study of the metastatic potential of B16 melanoma in knock-out (PAR2-/-) animals.
Matěj R, Zadinová M, Poučková P, Kukal J, Olejár T. Matěj R, et al. Folia Biol (Praha). 2012;58(2):81-6. Folia Biol (Praha). 2012. PMID: 22578959 Free article.
In the present study, we investigated differences of metastatic spread of B16 melanoma in knock-out animals compared with C57Bl6 mice. Knock-out mice B6.Cg-F2rl1(tm1Mslb)/J (PAR2-/-) and C57Bl6 controls were subcutaneously inoculated with the B16 melanoma tissue cell line. …
In the present study, we investigated differences of metastatic spread of B16 melanoma in knock-out animals compared with C57Bl6 mice. Knock …
Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5.
Zeeh F, Witte D, Gädeken T, Rauch BH, Grage-Griebenow E, Leinung N, Fromm SJ, Stölting S, Mihara K, Kaufmann R, Settmacher U, Lehnert H, Hollenberg MD, Ungefroren H. Zeeh F, et al. Oncotarget. 2016 Jul 5;7(27):41095-41109. doi: 10.18632/oncotarget.9600. Oncotarget. 2016. PMID: 27248167 Free PMC article.
Since TGF-beta and PAR2 affect tumourigenesis by regulating migration, invasion and metastasis, we hypothesized that there is signalling crosstalk between them. ...
Since TGF-beta and PAR2 affect tumourigenesis by regulating migration, invasion and metastasis, we hypothesized that there is signall …